Git as an Encrypted Distributed Version Control System

This thesis develops and presents a secure Git implementation, Git Virtual Vault (GV2), for users of Git to work on sensitive projects with repositories located in unsecure distributed environments, such as in cloud computing. This scenario is common within the Department of Defense, as much work is of a sensitive nature. In order to provide security to Git, additional functionality is added for confidentiality and integrity protection. This thesis examines existing Git encryption implementations and baselines their performance compared to unencrypted Git. Real-world Git repositories are examined to characterize typical Git usage and determine if the existing Git encryption implementations are capable of efficient performance with regards to typical Git usage. This research shows that the existing Git encryption implementations do not provide efficient performance. This research develops an improved secure Git implementation, GV2, with transparent authenticated encryption. The fundamental contribution of this research is developing GV2 to perform Git garbage collection on plaintext data before encrypting the data. The result is a secure Git implementation that is transparent to the user with only a minor performance penalty, compared to unencrypted Git

Plugging the leak in Dengue shock

Recent structural and functional advances provide fresh insight into the biology of the dengue virus non-structural protein, NS1 and suggest new avenues of research. The work of our lab and others have shown that the secreted, hexameric form of NS1 has a systemic toxic effect, inducing inflammatory cytokines and acting directly on endothelial cells to produce the hallmark of dengue disease, vascular leak. We also demonstrated that NS1 exerts its toxic activity through recognition by the innate immune receptor TLR4, mimicking the bacterial endotoxin LPS. This monograph covers the background underpinning these new findings and discusses new avenues for antiviral and vaccine intervention